Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 17/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766165 | 1.00 | NOTUM (1.00) | NOTUMHTR2AHTR2CDRD2DRD4 | |
| SCHEMBL2375244 | 0.85 | NOTUM (0.73) | NOTUMHTR2AHTR2CDRD2DRD4 | |
| SCHEMBL5568858 | 0.83 | NOTUM (0.70) | NOTUMHTR2AHTR2CDRD2DRD4 | |
| SCHEMBL6687673 | 0.81 | NOTUM (0.71) | NOTUMCYP2D6CYP2C9 | |
| SCHEMBL3300297 | 0.81 | NOTUM (0.71) | NOTUMCYP2D6CYP2C9 | |
| SCHEMBL2619231 | 0.81 | NOTUM (1.00) | NOTUMDRD2DRD4CYP2D6CYP2C9 | |
| SCHEMBL4532424 | 0.81 | NOTUM (0.71) | NOTUMCYP2D6CYP2C9 | |
| SCHEMBL24874051 | 0.80 | NOTUM (0.69) | NOTUMCYP2D6CYP2C9 | |
| SCHEMBL5803030 | 0.80 | NOTUM (0.69) | NOTUMCYP2D6CYP2C9 | |
| SCHEMBL1127318 | 0.80 | NOTUM (1.00) | NOTUMDRD4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701954-A1 | N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005066165-A1 | N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2005-07-21 | — | — | WO | disclosed |