Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.40 |
| ▸ | HTR7 | P34969 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | HTR1B | P28222 | 2/20 | 0.40 |
| ▸ | HTR1F | P30939 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5768435 | 0.85 | TAAR1 (0.45) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL5793653 | 0.84 | HTR6 (0.42) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL5769061 | 0.82 | HTR6 (0.49) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL5093102 | 0.80 | HTR6 (0.54) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL5767683 | 0.80 | HTR6 (0.42) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL5768419 | 0.79 | HTR6 (0.41) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL5767786 | 0.79 | HTR6 (0.41) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL5767647 | 0.78 | HTR6 (0.46) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL6195999 | 0.77 | HTR6 (0.43) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL3257371 | 0.77 | HTR6 (0.48) | HTR6TAAR1HDAC1HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517909-B1 | NOVEL TETRACYCLIC ARYLCARBONYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY USEFUL AS THERAPEUTIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LTD (IN) | 2006-10-25 | — | — | EP | disclosed |