Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 11/20 | 0.40 |
| ▸ | MAP2 | P11137 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | ICOSLG | O75144 | 3/20 | 0.34 |
| ▸ | ICOS | Q9Y6W8 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800497 | 0.73 | CHUK (0.52) | CHUKICOSLGICOSDYRK1A | |
| SCHEMBL3454907 | 0.69 | CHUK (0.56) | CHUKICOSLGICOSDYRK1A | |
| SCHEMBL1798096 | 0.67 | CHUK (0.56) | CHUKICOSLGICOS | |
| SCHEMBL1800336 | 0.66 | CHUK (0.73) | CHUKICOSLGICOS | |
| SCHEMBL15455367 | 0.65 | GRM2 (0.47) | JAK2 | |
| SCHEMBL27473965 | 0.65 | MKNK1 (0.46) | JAK2NUDT1 | |
| SCHEMBL1799095 | 0.64 | CHUK (0.55) | CHUKDYRK1A | |
| SCHEMBL5802216 | 0.63 | CHUK (0.66) | CHUKMAP2JAK2ICOSLGICOS | |
| SCHEMBL30664147 | 0.63 | CCNB2 (0.42) | CHUKJAK2DYRK1A | |
| SCHEMBL20122901 | 0.63 | CCNB2 (0.42) | CHUKJAK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611134-A1 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004092167-A1 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-10-28 | — | — | WO | disclosed |