Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 2/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798677 | 0.81 | CHUK (0.55) | CHUKDYRK1ALMNAGABRPGABRD | |
| SCHEMBL1799540 | 0.81 | CHUK (0.55) | CHUKDYRK1AMAP3K14LMNAGABRP | |
| SCHEMBL20482755 | 0.76 | GABRA1 (0.52) | CHUKGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29453525 | 0.72 | CHUK (0.64) | CHUKLMNACYP1A2GAAHPGD | |
| SCHEMBL607827 | 0.72 | CHUK (0.64) | CHUKLMNACYP1A2GAAHPGD | |
| SCHEMBL2691029 | 0.71 | CHUK (1.00) | CHUKDYRK1AGABRPGABRDGABRA1 | |
| SCHEMBL29884747 | 0.71 | CHUK (1.00) | CHUKDYRK1AGABRPGABRDGABRA1 | |
| SCHEMBL29756451 | 0.71 | CHUK (1.00) | CHUKDYRK1AGABRPGABRDGABRA1 | |
| SCHEMBL25565271 | 0.71 | CHUK (0.50) | CHUKLMNACYP1A2GAAHPGD | |
| SCHEMBL11089249 | 0.70 | PDE10A (0.54) | CHUKDYRK1ALMNACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951801-B2 | For therapy of inflammatory disease and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |