Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 18/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154366 | 0.75 | MC4R (0.56) | MC4RKCNH2 | |
| SCHEMBL5766405 | 0.75 | MC4R (0.54) | MC4RKCNH2 | |
| SCHEMBL5766784 | 0.72 | KCNH2 (0.52) | MC4RKCNH2 | |
| SCHEMBL4823708 | 0.72 | MC4R (0.56) | MC4RKCNH2 | |
| SCHEMBL5766154 | 0.70 | KCNH2 (0.53) | MC4RKCNH2 | |
| SCHEMBL7206481 | 0.70 | KCNH2 (0.53) | MC4RKCNH2 | |
| SCHEMBL5767273 | 0.69 | MC4R (0.53) | MC4RKCNH2 | |
| SCHEMBL4823897 | 0.69 | MC4R (0.69) | MC4RKCNH2 | |
| SCHEMBL7206492 | 0.68 | KCNH2 (0.58) | MC4RKCNH2 | |
| SCHEMBL3728758 | 0.68 | MC4R (1.00) | MC4RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644337-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | Gene Logic, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005121100-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | GENE LOGIC INC. (US) | 2005-12-22 | — | — | WO | disclosed |