Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3271535 | 0.93 | ALDH1A1 (0.70) | NPC1SMN1; SMN2RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL1468838 | 0.93 | ALDH1A1 (0.70) | NPC1SMN1; SMN2RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL3271568 | 0.93 | ALDH1A1 (0.70) | NPC1SMN1; SMN2RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL630697 | 0.92 | SMN1; SMN2 (0.73) | NPC1SMN1; SMN2RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL28390258 | 0.90 | ALDH1A1 (0.58) | NPC1SMN1; SMN2RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL16025051 | 0.89 | SMN1; SMN2 (0.68) | NPC1SMN1; SMN2RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL631512 | 0.89 | SMN1; SMN2 (0.68) | NPC1SMN1; SMN2RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL14348062 | 0.89 | SMN1; SMN2 (0.68) | NPC1SMN1; SMN2RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL6178689 | 0.88 | NPC1 (0.60) | NPC1SMN1; SMN2RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL1507267 | 0.88 | NPC1 (0.67) | NPC1SMN1; SMN2RAB9ACYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667994-A1 | QUINOLONE ANTIBACTERIAL AGENTS | Warner-Lambert Company LLC (US) | 2006-06-14 | — | — | EP | disclosed |
| US-20050119231-A1 | Quinolone antibacterial agents | ELLSWORTH EDMUND L (US) | 2005-06-02 | — | — | US | disclosed |
| US-20050107423-A1 | Quinolone antibacterial agents | ELLSWORTH EDMUND L (US) | 2005-05-19 | — | — | US | disclosed |
| WO-2005026154-A1 | QUINOLONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-24 | — | — | WO | disclosed |
| WO-2005026165-A1 | QUINOLONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119231-A1 | Quinolone antibacterial agents | NQO2, MRPL21, TOP1 | NPC1 1057/4885SMN1; SMN2 3447/4885RAB9A 838/4885 |
| US-20050107423-A1 | Quinolone antibacterial agents | NQO2, MRPL21, TOP1 | NPC1 1057/4885SMN1; SMN2 3447/4885RAB9A 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.