Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
| ▸ | STK10 | O94804 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | LATS1 | O95835 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | APRT | P07741 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765634 | 0.87 | ALDH1A1 (0.55) | ALDH1A1MAPK1HPGDKMT2AMEN1 | |
| SCHEMBL5765302 | 0.87 | GAK (0.52) | HPGDKMT2AMEN1GAKRIPK2 | |
| SCHEMBL5764652 | 0.85 | MAP4K4 (0.47) | ALDH1A1HPGDGAKRIPK2ULK1 | |
| SCHEMBL5767002 | 0.83 | MAP4K4 (0.46) | ALDH1A1HPGDGAKRIPK2ULK1 | |
| SCHEMBL3840314 | 0.82 | MAP4K4 (0.48) | HPGDGAKRIPK2ULK1STK10 | |
| SCHEMBL3842680 | 0.80 | IRAK4 (0.52) | ALDH1A1HPGDGAKRIPK2ULK1 | |
| Morpholine SCHEMBL5764394 | 0.80 | IRAK4 (0.52) | GAKRIPK2ULK1STK10PRKD3 | |
| SCHEMBL5766850 | 0.80 | MAP4K4 (0.45) | GAKRIPK2ULK1STK10PRKD3 | |
| SCHEMBL5764136 | 0.80 | CKS1B (0.51) | HPGDGAKRIPK2ULK1STK10 | |
| SCHEMBL4678752 | 0.79 | MAP4K4 (0.73) | HPGDGAKRIPK2ULK1STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | disclosed |