Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Renzapride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A known ✓ | P46098 | 7/20 | 0.96 |
| ▸ | HTR3E known ✓ | A5X5Y0 | 3/20 | 0.96 |
| ▸ | HTR3B known ✓ | O95264 | 3/20 | 0.96 |
| ▸ | HTR3D known ✓ | Q70Z44 | 3/20 | 0.96 |
| ▸ | HTR3C known ✓ | Q8WXA8 | 3/20 | 0.96 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.96 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.78 |
| ▸ | HTR5A | P47898 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Renzapride SCHEMBL5371617 | 1.00 | HTR3A (0.96) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Renzapride SCHEMBL5765864 | 0.99 | HTR3A (0.98) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Renzapride SCHEMBL5371909 | 0.99 | HTR3A (0.98) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Renzapride SCHEMBL5367707 | 0.99 | HTR3A (0.98) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Renzapride SCHEMBL17037 | 0.98 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Renzapride SCHEMBL678616 | 0.98 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Renzapride SCHEMBL4534994 | 0.98 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Renzapride SCHEMBL1650356 | 0.96 | HTR3A (0.96) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Zacopride SCHEMBL29389976 | 0.88 | MAPK1 (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Zacopride SCHEMBL9598323 | 0.88 | MAPK1 (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239321-B1 | CHEMICAL COMPOUND | BEECHAM GROUP PLC (GB) | 1993-06-16 | — | — | EP | claimed |
| EP-1699789-A2 | SYNTHESIS OF A POLYMORPH OF 4-AMINO-5-CHLORO-2-METHOXY-N-(1-AZABICYCLO[3.3.1]NON-4-YL)BENZAMIDE HYDROCHLORIDE HYDRATE | Alizyme Therapeutics Limited (GB) | 2006-09-13 | — | — | EP | disclosed |
| EP-0239321-B1 | CHEMICAL COMPOUND | BEECHAM GROUP PLC (GB) | 1993-06-16 | — | — | EP | disclosed |