Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396185 | 0.89 | SPPL2A (0.43) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL5770476 | 0.87 | LMNA (0.42) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL5770470 | 0.87 | LMNA (0.42) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL7395965 | 0.85 | MLNR (0.50) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL5770232 | 0.84 | MLNR (0.44) | MLNRABCB11LMNACTSDCYP3A4 | |
| SCHEMBL5770234 | 0.84 | MLNR (0.44) | MLNRABCB11LMNACTSDCYP3A4 | |
| SCHEMBL7397547 | 0.83 | SPPL2A (0.37) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL5770037 | 0.81 | SPPL2A (0.40) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL1602311 | 0.80 | ABCB1 (0.62) | MLNRABCB11LMNACTSDCYP3A4 | |
| SCHEMBL5769249 | 0.80 | SPPL2A (0.37) | SPPL2AMLNRABCB11LMNACTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1637518-A2 | Inhibitors of aspartyl protease | Vertex Pharmaceuticals Incorporated (US) | 2006-03-22 | — | — | EP | disclosed |