Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27382541 | 0.89 | ITGB2 (0.53) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL15982628 | 0.80 | LMNA (0.60) | MAPTSMN1; SMN2GAAPOLBKMT2A | |
| SCHEMBL15982312 | 0.80 | LMNA (0.60) | MAPTSMN1; SMN2GAAPOLBKMT2A | |
| SCHEMBL15982613 | 0.80 | LMNA (0.60) | MAPTSMN1; SMN2GAAPOLBKMT2A | |
| SCHEMBL12732266 | 0.76 | ITGB2 (0.47) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL1134704 | 0.76 | CYP3A4 (0.48) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL18873211 | 0.73 | CYP3A4 (0.41) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL86325 | 0.72 | MAOB (0.53) | SMN1; SMN2ALDH1A1NPC1RAB9ANFKB1 | |
| SCHEMBL22763282 | 0.72 | CMA1 (0.42) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL20225725 | 0.71 | PDCD1 (0.46) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | disclosed |