Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 19/20 | 0.61 |
| ▸ | CCR5 | P51681 | 4/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770110 | 1.00 | CCR2 (0.61) | CCR2CCR5KCNH2MEN1KMT2A | |
| SCHEMBL5769129 | 0.93 | CCR2 (0.63) | CCR2CCR5KCNH2MEN1KMT2A | |
| SCHEMBL3733104 | 0.87 | CCR2 (0.78) | CCR2CCR5KCNH2 | |
| SCHEMBL3734930 | 0.87 | CCR2 (0.78) | CCR2CCR5KCNH2 | |
| SCHEMBL3734932 | 0.87 | CCR2 (0.78) | CCR2CCR5KCNH2 | |
| SCHEMBL3733100 | 0.87 | CCR2 (0.78) | CCR2CCR5KCNH2 | |
| SCHEMBL15310518 | 0.86 | CCR2 (0.60) | CCR2CCR5KCNH2MEN1KMT2A | |
| SCHEMBL5820063 | 0.86 | CCR2 (0.60) | CCR2CCR5KCNH2MEN1KMT2A | |
| SCHEMBL5767261 | 0.85 | CCR2 (0.77) | CCR2CCR5KCNH2 | |
| SCHEMBL5767886 | 0.85 | CCR2 (0.61) | CCR2CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656345-A1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005021500-A1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-03-10 | — | — | WO | disclosed |