Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 5/20 | 0.77 |
| ▸ | EGFR | P00533 | 6/20 | 0.74 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.73 |
| ▸ | INSR | P06213 | 7/20 | 0.73 |
| ▸ | IGF1R | P08069 | 7/20 | 0.73 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.69 |
| ▸ | PLK4 | O00444 | 1/20 | 0.69 |
| ▸ | STK25 | O00506 | 1/20 | 0.69 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.69 |
| ▸ | CASK | O14936 | 1/20 | 0.69 |
| ▸ | AURKA | O14965 | 1/20 | 0.69 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.69 |
| ▸ | MUSK | O15146 | 1/20 | 0.69 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.69 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.69 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780500 | 0.95 | ZAP70 (0.70) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL26092640 | 0.94 | INSR (0.84) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL12728763 | 0.91 | ZAP70 (0.64) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL1061877 | 0.90 | ALK (0.72) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL12780998 | 0.89 | EGFR (0.77) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL1911929 | 0.88 | ALK (0.88) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL12780039 | 0.88 | EGFR (0.71) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL12781009 | 0.87 | ZAP70 (0.80) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL12780131 | 0.87 | ZAP70 (1.00) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL4096584 | 0.87 | EGFR (0.71) | ZAP70EGFRALKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660458-A1 | 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | Novartis AG (CH) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005016894-A1 | 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2005-02-24 | — | — | WO | disclosed |