Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | MC4R | P32245 | 15/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767776 | 0.85 | KCNH2 (0.52) | KCNH2MC4RLMNAHPGD | |
| SCHEMBL5766784 | 0.85 | KCNH2 (0.52) | KCNH2MC4RLMNAHPGD | |
| SCHEMBL5766403 | 0.82 | KCNH2 (0.50) | KCNH2MC4RLMNAHPGD | |
| SCHEMBL7206481 | 0.81 | KCNH2 (0.53) | KCNH2MC4R | |
| SCHEMBL5766154 | 0.81 | KCNH2 (0.53) | KCNH2MC4RLMNAHPGD | |
| SCHEMBL7206492 | 0.81 | KCNH2 (0.58) | KCNH2MC4RLMNAHPGD | |
| SCHEMBL5767273 | 0.81 | MC4R (0.53) | KCNH2MC4RLMNAHPGD | |
| SCHEMBL5767311 | 0.80 | KCNH2 (0.50) | KCNH2MC4RLMNAHPGD | |
| SCHEMBL5763829 | 0.79 | KCNH2 (0.50) | KCNH2MC4RLMNAHPGD | |
| SCHEMBL5767468 | 0.77 | KCNH2 (0.48) | KCNH2MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644337-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | Gene Logic, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005121100-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | GENE LOGIC INC. (US) | 2005-12-22 | — | — | WO | disclosed |