SCHEMBL5769130

SCHEMBL5769130

CCn1c(-c2ccc(Cl)cc2)nc2c(=O)[nH]c(SCCCF)nc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.46
TSHR P16473 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46
KDM4E B2RXH2 3/20 0.41
PKM P14618 2/20 0.41
HPGD P15428 1/20 0.41
LMNA P02545 3/20 0.41
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37
GAA P10253 2/20 0.37
GFER P55789 1/20 0.36
APOBEC3G Q9HC16 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
HTT P42858 2/20 0.35
POLB P06746 1/20 0.35
CREBBP Q92793 1/20 0.35
MAPT P10636 1/20 0.35
TP53 P04637 1/20 0.35
MAPK1 P28482 1/20 0.35
RUNX1 Q01196 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5766787 0.91 ALDH1A1 (0.52) ALDH1A1TSHRNPSR1KDM4EPKM
SCHEMBL5769419 0.90 ALDH1A1 (0.45) ALDH1A1TSHRNPSR1KDM4EPKM
SCHEMBL5768787 0.89 ALDH1A1 (0.47) ALDH1A1TSHRNPSR1KDM4EPKM
SCHEMBL5766852 0.87 ALDH1A1 (0.41) ALDH1A1TSHRNPSR1KDM4EPKM
SCHEMBL5769296 0.86 ALDH1A1 (0.42) ALDH1A1TSHRNPSR1KDM4EPKM
SCHEMBL5769810 0.84 ALDH1A1 (0.40) ALDH1A1TSHRNPSR1KDM4EPKM
SCHEMBL5769602 0.83 HPGD (0.43) ALDH1A1TSHRNPSR1KDM4EPKM
SCHEMBL5768343 0.82 ALDH1A1 (0.38) ALDH1A1TSHRNPSR1KDM4EPKM
SCHEMBL5769417 0.82 ALDH1A1 (0.39) ALDH1A1TSHRNPSR1KDM4EPKM
SCHEMBL5768642 0.81 ALDH1A1 (0.37) ALDH1A1TSHRNPSR1KDM4EPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1687306-A1 BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) MERCK SHARP & DOHME LTD. (GB) 2006-08-09 EP claimed
WO-2005049613-A1 BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) MERCK SHARP & DOHME LIMITED (GB) 2005-06-02 WO claimed
EP-1687306-A1 BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) MERCK SHARP & DOHME LTD. (GB) 2006-08-09 EP disclosed
WO-2005049613-A1 BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) MERCK SHARP & DOHME LIMITED (GB) 2005-06-02 WO disclosed