Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 10/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | FOS | P01100 | 1/20 | 0.34 |
| ▸ | JUN | P05412 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5768259 | 0.85 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3CYP1A2 | |
| SCHEMBL5768001 | 0.83 | GABRA1 (0.45) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5770639 | 0.81 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5771693 | 0.80 | GABRA1 (0.44) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5770171 | 0.75 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5771981 | 0.75 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5769651 | 0.75 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5769692 | 0.75 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRA3PKM | |
| SCHEMBL5771286 | 0.74 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5770532 | 0.72 | GABRA1 (0.51) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383768-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-09-06 | — | — | EP | disclosed |