Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 18/20 | 0.67 |
| ▸ | GABRG2 | P18507 | 18/20 | 0.67 |
| ▸ | GABRB3 | P28472 | 18/20 | 0.67 |
| ▸ | GABRA3 | P34903 | 17/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767469 | 0.88 | GABRA1 (0.50) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL5771659 | 0.86 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL5769692 | 0.85 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL5769651 | 0.85 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL5771981 | 0.85 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL5771286 | 0.85 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL5770639 | 0.85 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL5770171 | 0.84 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL5767918 | 0.82 | GABRA1 (0.44) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL5770982 | 0.82 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383768-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-09-06 | — | — | EP | disclosed |