Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | IKBKB | O14920 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14817171 | 0.84 | TUBB4A (0.44) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL6232939 | 0.80 | MAPT (0.56) | MAPTALDH1A1IKBKBKDM4ERAB9A | |
| SCHEMBL12777778 | 0.80 | MAPT (0.45) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL12673349 | 0.77 | MAPT (0.54) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL12529390 | 0.77 | MAPT (0.54) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL16272782 | 0.76 | CYP3A4 (0.35) | MAPTALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL5362627 | 0.74 | MAPT (1.00) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL28122768 | 0.73 | CCR1 (0.45) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL4097325 | 0.72 | IKBKB (1.00) | MAPTALDH1A1POLBIKBKBKDM4E | |
| SCHEMBL1144476 | 0.72 | IKBKB (0.77) | MAPTALDH1A1POLBIKBKBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |