Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.56 |
| ▸ | ITK | Q08881 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PTPRF | P10586 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770868 | 0.91 | CPT2 (0.46) | LRRK2ITKFGFR1FLT1CYP1A1 | |
| SCHEMBL5767357 | 0.84 | HPGD (0.57) | LRRK2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL26911852 | 0.83 | LRRK2 (0.72) | LRRK2ITKFGFR1FLT1NPC1 | |
| SCHEMBL29548155 | 0.83 | LRRK2 (0.72) | LRRK2ITKFGFR1FLT1NPC1 | |
| SCHEMBL5772080 | 0.81 | KDM4E (0.60) | LRRK2ARNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5813034 | 0.80 | LRRK2 (0.55) | LRRK2ITKFGFR1FLT1CYP1A1 | |
| SCHEMBL22543358 | 0.79 | CYP1A1 (0.62) | CYP1A1CYP1A2CYP1B1ARNPC1 | |
| SCHEMBL5777148 | 0.79 | KDM4E (0.63) | ITKNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5771544 | 0.79 | CYP19A1 (0.51) | CYP1A1CYP1A2CYP1B1NPC1RAB9A | |
| SCHEMBL5771063 | 0.79 | LRRK2 (0.54) | LRRK2ITKFGFR1FLT1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664040-A1 | GYRASE INHIBITORS | PFIZER INC. (US) | 2006-06-07 | — | — | EP | disclosed |
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
| WO-2005026162-A1 | GYRASE INHIBITORS | PFIZER INC. (US) | 2005-03-24 | — | — | WO | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | LRRK2 2922/4885ITK 1969/4885FGFR1 3930/4885 |
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | LRRK2 2922/4885ITK 1969/4885FGFR1 3930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.