Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 4/20 | 0.46 |
| ▸ | GABRD | O14764 | 4/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.46 |
| ▸ | GABRE | P78334 | 4/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14542423 | 0.84 | MAOB (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL5776260 | 0.83 | MAOB (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL20660658 | 0.77 | RAB9A (0.48) | KDM4ENPC1ALDH1A1TP53HPGD | |
| SCHEMBL5774805 | 0.74 | ESR1 (0.40) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15086424 | 0.74 | KDM4E (0.43) | MAOBKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL9947476 | 0.73 | MAOB (0.71) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL735803 | 0.73 | MAOB (0.71) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7916567 | 0.71 | CYP1A2 (0.48) | KDM4ENPC1ALDH1A1TP53HPGD | |
| SCHEMBL16918303 | 0.71 | MAOB (0.54) | MAOBTNKSPARP1TNKS2KDM4E | |
| SCHEMBL2760352 | 0.71 | KDM4E (0.81) | KDM4ENPC1ALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |