Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.73 |
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5904492 | 1.00 | HRH4 (1.00) | HRH4HRH3PDE10A | |
| SCHEMBL5772807 | 0.85 | HRH4 (0.73) | HRH4HRH3PDE10A | |
| SCHEMBL5773824 | 0.84 | HRH4 (0.72) | HRH4HRH3PDE10A | |
| SCHEMBL2631199 | 0.83 | HRH4 (0.71) | HRH4PDE10A | |
| SCHEMBL5769653 | 0.83 | HRH4 (0.83) | HRH4HRH3PDE10A | |
| SCHEMBL5773503 | 0.83 | HRH4 (0.83) | HRH4HRH3 | |
| SCHEMBL5770148 | 0.83 | HRH4 (0.70) | HRH4HRH3 | |
| SCHEMBL604426 | 0.82 | HRH4 (1.00) | HRH4HRH3PDE10A | |
| SCHEMBL5771734 | 0.82 | HRH4 (0.69) | HRH4HRH3 | |
| SCHEMBL5773269 | 0.81 | HRH4 (0.68) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1671972-A1 | Octahydropyrrolo[3,4-c]pyrrole derivatives | Pfizer Limited (GB) | 2006-06-21 | — | — | EP | claimed |
| EP-1671972-A1 | Octahydropyrrolo[3,4-c]pyrrole derivatives | Pfizer Limited (GB) | 2006-06-21 | — | — | EP | disclosed |