Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 19/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.66 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773779 | 0.88 | HRH4 (0.65) | HRH4HRH3TLR9TLR8TLR7 | |
| SCHEMBL5773824 | 0.86 | HRH4 (0.72) | HRH4HRH3 | |
| SCHEMBL5770148 | 0.85 | HRH4 (0.70) | HRH4HRH3 | |
| SCHEMBL5773503 | 0.85 | HRH4 (0.83) | HRH4HRH3 | |
| SCHEMBL5769653 | 0.85 | HRH4 (0.83) | HRH4HRH3 | |
| SCHEMBL5772807 | 0.84 | HRH4 (0.73) | HRH4HRH3 | |
| SCHEMBL5773514 | 0.83 | HRH4 (0.67) | HRH4HRH3 | |
| SCHEMBL5770715 | 0.82 | HRH4 (0.67) | HRH4HRH3 | |
| SCHEMBL5904441 | 0.82 | HRH4 (0.66) | HRH4HRH3 | |
| SCHEMBL5904492 | 0.82 | HRH4 (1.00) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1671972-A1 | Octahydropyrrolo[3,4-c]pyrrole derivatives | Pfizer Limited (GB) | 2006-06-21 | — | — | EP | claimed |
| EP-1671972-A1 | Octahydropyrrolo[3,4-c]pyrrole derivatives | Pfizer Limited (GB) | 2006-06-21 | — | — | EP | disclosed |
| US-20060111416-A1 | Octahydropyrrolo[3,4-C]pyrrole derivatives | PFIZER INC. | 2006-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111416-A1 | Octahydropyrrolo[3,4-C]pyrrole derivatives | DPYD, PAH, DHPS | HRH4 1986/4885HRH3 3821/4885TLR9 4498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.