⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL944938 | 0.69 | — | — | |
| SCHEMBL720628 | 0.69 | ALDH1A1 (0.31) | — | |
| SCHEMBL5972794 | 0.68 | — | — | |
| SCHEMBL5611388 | 0.67 | — | — | |
| SCHEMBL5859922 | 0.67 | SMPD1 (0.31) | — | |
| SCHEMBL7096450 | 0.67 | FOLH1 (0.32) | — | |
| SCHEMBL6113548 | 0.65 | — | — | |
| SCHEMBL9872504 | 0.65 | TDP1 (0.39) | — | |
| SCHEMBL2058252 | 0.65 | MAPK1 (0.30) | — | |
| SCHEMBL22023061 | 0.65 | ALDH1A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | claimed |
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | claimed |
| EP-1003721-A1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LIMITED (GB) | 2000-05-31 | — | — | EP | claimed |
| WO-1999021859-A1 | AZAOXINDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-05-06 | — | — | WO | claimed |
| WO-1999010325-A1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LIMITED (GB) | 1999-03-04 | — | — | WO | claimed |
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |
| US-20050250837-A1 | Use of C-Raf inhibitors for the treatment of neurodegenerative diseases | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2005-11-10 | — | — | US | disclosed |
| WO-2004064733-A2 | THE USE OF C-RAF INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2004-08-05 | — | — | WO | disclosed |
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |
| EP-1003721-A1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LIMITED (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999021859-A1 | AZAOXINDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-05-06 | — | — | WO | disclosed |
| WO-1999010325-A1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |
| EP-0102062-B1 | 1,3-DITHIANES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1988-11-23 | — | — | EP | disclosed |
| US-4640929-A | Insecticidally, acaricidally, and nematocidally 2-amino-1,3-dithiane derivatives and pesticidal compositions therefor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-02-03 | — | — | US | disclosed |
| EP-0102062-A2 | 1,3-Dithianes, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1984-03-07 | — | — | EP | disclosed |