Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.63 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099472 | 0.80 | CRHR1 (0.76) | CRHR1 | |
| SCHEMBL5103262 | 0.78 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL5100104 | 0.78 | CRHR1 (0.64) | CRHR1CNR2CNR1 | |
| SCHEMBL5102914 | 0.78 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL5103479 | 0.77 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL5106141 | 0.77 | CRHR1 (0.88) | CRHR1 | |
| SCHEMBL5099557 | 0.74 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL5112342 | 0.72 | CRHR1 (0.57) | CRHR1CNR2CNR1 | |
| SCHEMBL5099518 | 0.70 | CRHR1 (0.57) | CRHR1CNR2CNR1 | |
| SCHEMBL5054087 | 0.69 | CRHR1 (0.68) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383498-B1 | CRF RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2006-03-15 | — | — | EP | disclosed |