Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.70 |
| ▸ | AURKA | O14965 | 16/20 | 0.70 |
| ▸ | TEK | Q02763 | 16/20 | 0.70 |
| ▸ | LCK | P06239 | 12/20 | 0.70 |
| ▸ | MET | P08581 | 14/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.65 |
| ▸ | LYN | P07948 | 2/20 | 0.65 |
| ▸ | FLT1 | P17948 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | FGR | P09769 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5769862 | 0.91 | KDR (0.83) | KDRAURKATEKLCKMET | |
| SCHEMBL5773976 | 0.86 | KDR (0.76) | KDRAURKATEKLCKMET | |
| SCHEMBL5771857 | 0.85 | KDR (0.86) | KDRAURKATEKLCKMET | |
| SCHEMBL5770590 | 0.84 | KDR (0.64) | KDRAURKATEKLCKMET | |
| SCHEMBL4548688 | 0.83 | KDR (1.00) | KDRAURKATEKLCKMET | |
| SCHEMBL2746887 | 0.81 | KDR (1.00) | KDRAURKATEKLCKMET | |
| SCHEMBL6316909 | 0.81 | KDR (0.64) | KDRAURKATEKLCKMET | |
| SCHEMBL4548834 | 0.81 | KDR (1.00) | KDRAURKATEKLCKMET | |
| SCHEMBL4549038 | 0.80 | KDR (0.84) | KDRAURKATEKLCKMET | |
| SCHEMBL1618095 | 0.80 | KDR (0.46) | KDRAURKATEKLCKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660503-A1 | NAPHTHALENE CARBOXAMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS | PFIZER INC. (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005021553-A1 | NAPHTHALENE CARBOXAMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS | PFIZER INC. (US) | 2005-03-10 | — | — | WO | disclosed |