Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.57 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | DRD3 | P35462 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774777 | 0.90 | HTR6 (0.56) | HTR6DRD2DRD3HTR1AHTR2A | |
| SCHEMBL3209365 | 0.90 | HTR6 (0.70) | HTR6DRD2DRD3HTR1AHTR2A | |
| SCHEMBL5772333 | 0.89 | HTR6 (0.54) | HTR6DRD2DRD3HTR1AHTR2A | |
| SCHEMBL5772310 | 0.89 | HTR6 (0.54) | HTR6DRD2DRD3HTR1AHTR2A | |
| SCHEMBL5771499 | 0.87 | HTR6 (0.52) | HTR6DRD2DRD3HTR1A | |
| SCHEMBL3212054 | 0.87 | HTR6 (0.52) | HTR6DRD2DRD3HTR1AHTR2A | |
| SCHEMBL5775637 | 0.85 | HTR6 (0.51) | HTR6DRD2DRD3HTR1A | |
| SCHEMBL5738248 | 0.84 | HTR6 (0.59) | HTR6DRD2DRD3HTR1AHTR2A | |
| SCHEMBL13422076 | 0.83 | HTR6 (0.82) | HTR6 | |
| SCHEMBL3198398 | 0.80 | HTR6 (0.52) | HTR6DRD2DRD3HTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682502-A1 | SULFONYLTETRAHYDRO-3H-BENZO(E)INDOLE-8-AMINE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005047252-A1 | SULFONYLTETRAHYDRO-3H-BENZO(E)INDOLE-8-AMINE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-05-26 | — | — | WO | claimed |
| EP-1682502-A1 | SULFONYLTETRAHYDRO-3H-BENZO(E)INDOLE-8-AMINE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005047252-A1 | SULFONYLTETRAHYDRO-3H-BENZO(E)INDOLE-8-AMINE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-05-26 | — | — | WO | disclosed |