Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 20/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 20/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 18/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221519 | 0.90 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5261894 | 0.87 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6219147 | 0.87 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5772206 | 0.84 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5769238 | 0.83 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6218533 | 0.80 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6217329 | 0.80 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5768203 | 0.77 | GABRA1 (0.81) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5769142 | 0.76 | GABRA1 (0.38) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6219080 | 0.76 | GABRA1 (0.36) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383768-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-09-06 | — | — | EP | disclosed |
| EP-1381606-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2005-07-20 | — | — | EP | disclosed |