Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803938 | 0.89 | P2RX7 (0.73) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL1804074 | 0.85 | P2RX7 (0.62) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL1805790 | 0.85 | P2RX7 (0.62) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL1804656 | 0.85 | P2RX7 (0.61) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL3837447 | 0.84 | P2RX7 (0.63) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL1807655 | 0.83 | P2RX7 (0.62) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL3839473 | 0.83 | P2RX7 (0.59) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL3857335 | 0.82 | P2RX7 (0.61) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| Hydrochloric Acid SCHEMBL3842411 | 0.82 | P2RX7 (0.61) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL3836528 | 0.82 | P2RX7 (0.58) | P2RX7L3MBTL1EPHX2ROCK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633717-A1 | NEW P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | AstraZeneca AB (SE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004106305-A1 | NEW P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-12-09 | — | — | WO | disclosed |