Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 13/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 13/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777844 | 0.84 | PTGDR (0.35) | TBXA2RPTGDRPTGER2GRIN2DGRIN3B | |
| SCHEMBL5777080 | 0.82 | FFAR1 (0.35) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL5836711 | 0.80 | AKR1C3 (0.32) | TBXA2RPTGDRPTGER2 | |
| SCHEMBL5775908 | 0.76 | PTGDR (0.44) | TBXA2RPTGDRPTGER2 | |
| SCHEMBL5774572 | 0.76 | PTGDR (0.44) | TBXA2RPTGDRPTGER2 | |
| SCHEMBL5778075 | 0.76 | GRIN2D (0.39) | TBXA2RPTGDRPTGER2GRIN2DGRIN3B | |
| SCHEMBL5776905 | 0.75 | PTGDR (0.42) | TBXA2RPTGDRPTGER2GRIN2DGRIN3B | |
| SCHEMBL2926752 | 0.73 | GRIN2D (0.36) | TBXA2RPTGDRPTGER2GRIN2DGRIN3B | |
| SCHEMBL5777134 | 0.71 | FFAR4 (0.35) | TBXA2RPTGDRGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5776227 | 0.70 | PDE2A (0.34) | TBXA2RPTGDRPTGER2GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |