Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.82 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773503 | 0.87 | HRH4 (0.83) | HRH4HRH3ALOX15 | |
| SCHEMBL5775412 | 0.84 | HRH4 (0.84) | HRH4HRH3PDE10AALOX15 | |
| SCHEMBL5775764 | 0.84 | HRH4 (0.84) | HRH4HRH3PDE10AALOX15 | |
| SCHEMBL5771245 | 0.83 | HRH4 (0.66) | HRH4HRH3PDE10AALOX15 | |
| SCHEMBL4321676 | 0.81 | PARP1 (0.58) | HRH4HRH3PDE10AALOX15HTR3A | |
| SCHEMBL4321670 | 0.81 | PARP1 (0.58) | HRH4HRH3PDE10AALOX15HTR3A | |
| SCHEMBL4321673 | 0.81 | PARP1 (0.58) | HRH4HRH3PDE10AALOX15HTR3A | |
| SCHEMBL604697 | 0.81 | HRH4 (0.64) | HRH4HRH3ALOX15 | |
| SCHEMBL5775848 | 0.80 | HRH4 (0.76) | HRH4HRH3 | |
| SCHEMBL603231 | 0.78 | HRH4 (0.54) | HRH4HRH3PDE10AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1671972-A1 | Octahydropyrrolo[3,4-c]pyrrole derivatives | Pfizer Limited (GB) | 2006-06-21 | — | — | EP | claimed |
| EP-1671972-A1 | Octahydropyrrolo[3,4-c]pyrrole derivatives | Pfizer Limited (GB) | 2006-06-21 | — | — | EP | disclosed |
| US-20060111416-A1 | Octahydropyrrolo[3,4-C]pyrrole derivatives | PFIZER INC. | 2006-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111416-A1 | Octahydropyrrolo[3,4-C]pyrrole derivatives | DPYD, PAH, DHPS | HRH4 1986/4885HRH3 3821/4885PDE10A 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.