Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 3/20 | 0.35 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5776151 | 0.99 | ADORA3 (0.40) | ADORA3ADORA2AADORA1KDM4EHPGD | |
| SCHEMBL5796755 | 0.79 | ADORA3 (0.43) | ADORA3ADORA2AADORA1KDM4EHPGD | |
| SCHEMBL5772983 | 0.77 | KDM4E (0.49) | ADORA3ADORA2AADORA1KDM4EHPGD | |
| SCHEMBL5775603 | 0.76 | ADORA3 (0.50) | ADORA3ADORA2AADORA1KDM4EHPGD | |
| SCHEMBL5774390 | 0.75 | KDM4E (0.59) | KDM4EHPGDSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL5772874 | 0.75 | KDM4E (0.47) | ADORA3ADORA2AADORA1KDM4EHPGD | |
| SCHEMBL5776173 | 0.74 | NPY5R (0.51) | ADORA3ADORA2AADORA1KDM4EHPGD | |
| SCHEMBL5774543 | 0.74 | ADORA1 (0.48) | ADORA3ADORA2AADORA1KDM4EHPGD | |
| SCHEMBL5771758 | 0.74 | ADORA2A (0.48) | ADORA3ADORA2AADORA1KDM4EHPGD | |
| SCHEMBL5774357 | 0.74 | ADORA3 (0.48) | ADORA3ADORA2AADORA1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |