Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770635 | 0.95 | MAPK14 (0.36) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5767898 | 0.94 | MAPK14 (0.35) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5769793 | 0.93 | ALDH1A1 (0.37) | MAPK14MAPK13MAPK12MAPK11USP2 | |
| SCHEMBL5768583 | 0.89 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11USP2 | |
| SCHEMBL5770214 | 0.88 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5769579 | 0.88 | MAPK13 (0.41) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5770975 | 0.86 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11CYP1A2 | |
| SCHEMBL5770571 | 0.86 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5773285 | 0.86 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5771199 | 0.86 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988301-B1 | IMIDAZOLYL-CYCLIC ACETALS | AVENTIS PHARMA LTD (GB) | 2006-08-09 | — | — | EP | disclosed |
| US-6989395-B2 | Imidazolyl-cyclic acetals | AVENTIS PHARMA LIMITED (GB) | 2006-01-24 | — | — | US | disclosed |
| US-6602877-B1 | Imidazolyl-cyclic acetals | AVENTIS PHARMA LIMITED (GB) | 2003-08-05 | — | — | US | disclosed |
| EP-0988301-A1 | IMIDAZOLYL-CYCLIC ACETALS | RHONE-POULENC RORER LIMITED (GB) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998056788-A1 | IMIDAZOLYL-CYCLIC ACETALS | RHONE-POULENC RORER LIMITED (GB) | 1998-12-17 | — | — | WO | disclosed |