Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 3/20 | 0.35 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.35 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26615047 | 1.00 | SLC6A12 (0.35) | SLC6A12SLC6A11SLC6A13SIGABRR1 | |
| SCHEMBL26614925 | 1.00 | SLC6A12 (0.35) | SLC6A12SLC6A11SLC6A13SIGABRR1 | |
| SCHEMBL2873603 | 1.00 | SLC6A12 (0.35) | SLC6A12SLC6A11SLC6A13SIGABRR1 | |
| SCHEMBL2873601 | 1.00 | SLC6A12 (0.35) | SLC6A12SLC6A11SLC6A13SIGABRR1 | |
| SCHEMBL1586267 | 1.00 | SLC6A12 (0.35) | SLC6A12SLC6A11SLC6A13SIGABRR1 | |
| Hydrochloric Acid SCHEMBL21682454 | 0.98 | SLC6A12 (0.38) | SLC6A12SLC6A11SLC6A13SI | |
| SCHEMBL3372261 | 0.84 | POLB (0.32) | — | |
| SCHEMBL2908775 | 0.84 | POLB (0.32) | — | |
| SCHEMBL2908778 | 0.84 | POLB (0.32) | — | |
| SCHEMBL1924790 | 0.83 | SLC6A12 (0.35) | SLC6A12SLC6A11SLC6A13GABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |