Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388935 | 0.88 | GPR119 (0.98) | GPR119CYP2C9KCNH2 | |
| SCHEMBL390855 | 0.87 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389364 | 0.86 | GPR119 (0.97) | GPR119CYP2C9KCNH2 | |
| SCHEMBL388694 | 0.80 | GPR119 (0.91) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389596 | 0.80 | GPR119 (0.86) | GPR119CYP2C9KCNH2 | |
| SCHEMBL390018 | 0.78 | GPR119 (0.83) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389690 | 0.78 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| SCHEMBL13404689 | 0.77 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389554 | 0.77 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| SCHEMBL13404688 | 0.77 | GPR119 (1.00) | GPR119CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644375-A2 | FUSED-ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005007658-A2 | FUSED-ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | disclosed |