Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 18/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 17/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 16/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 16/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 13/20 | 0.44 |
| ▸ | TSHR | P16473 | 11/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.44 |
| ▸ | LMNA | P02545 | 10/20 | 0.44 |
| ▸ | USP2 | O75604 | 8/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777606 | 0.76 | ABCB1 (0.39) | HSD17B10ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL8126898 | 0.76 | IGF1R (0.39) | NPY5RCLK4HSD17B10ALDH1A1LMNA | |
| SCHEMBL5777863 | 0.75 | NPY5R (0.48) | NPY5RHSD17B10ALDH1A1LMNAMAPT | |
| SCHEMBL5773457 | 0.72 | NPY5R (1.00) | NPY5RCYP1A2CYP2C19CYP2D6CYP3A4 | |
| SCHEMBL5776191 | 0.70 | KDM4E (0.40) | HSD17B10ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL5775603 | 0.70 | ADORA3 (0.50) | HSD17B10ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL1733562 | 0.68 | KDM4E (0.59) | NPY5RCYP1A2CYP2C19CYP2D6CYP3A4 | |
| SCHEMBL5775434 | 0.68 | NPY5R (0.39) | NPY5RCYP1A2TSHRHSD17B10ALDH1A1 | |
| SCHEMBL5771758 | 0.68 | ADORA2A (0.48) | NPY5RHSD17B10ALDH1A1MAPTKDM4E | |
| SCHEMBL5774543 | 0.68 | ADORA1 (0.48) | HSD17B10ALDH1A1MAPTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |