Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 18/20 | 0.53 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805890 | 1.00 | P2RX7 (0.53) | P2RX7OGFRL1KCNQ3KCNQ2 | |
| SCHEMBL1807800 | 0.92 | P2RX7 (0.54) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL1802618 | 0.90 | P2RX7 (0.59) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL1802169 | 0.90 | P2RX7 (0.59) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL29394286 | 0.90 | P2RX7 (0.59) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL3843926 | 0.89 | P2RX7 (0.48) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL1804098 | 0.89 | P2RX7 (0.54) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL3837025 | 0.89 | P2RX7 (0.54) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL3837713 | 0.88 | P2RX7 (0.51) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL5744327 | 0.86 | P2RX7 (0.68) | P2RX7KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633717-A1 | NEW P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | AstraZeneca AB (SE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004106305-A1 | NEW P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-12-09 | — | — | WO | disclosed |