Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 11/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3873883 | 0.83 | FAAH (0.33) | FAAH | |
| SCHEMBL5775485 | 0.69 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL3873948 | 0.67 | — | — | |
| SCHEMBL5777473 | 0.63 | — | — | |
| SCHEMBL3873891 | 0.62 | PI4KB (0.33) | FAAH | |
| SCHEMBL3871717 | 0.56 | SMN1; SMN2 (0.34) | — | |
| SCHEMBL10053489 | 0.55 | CA12 (0.61) | — | |
| SCHEMBL9378748 | 0.54 | DAO (0.50) | — | |
| SCHEMBL6167127 | 0.53 | TAAR1 (0.48) | — | |
| SCHEMBL9068363 | 0.52 | HDAC1 (0.51) | HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682524-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005040142-A9 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | AVENTIS PHARMA INC (US) | 2005-06-09 | — | — | WO | claimed |
| WO-2005040142-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-06 | — | — | WO | claimed |