Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 16/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7959917 | 0.99 | NPY5R (0.40) | NPY5RKCNMA1KDM4ELMNAHTT | |
| SCHEMBL25251956 | 0.69 | BCHE (0.46) | NPY5RKDM4ESMN1; SMN2NPSR1HPGD | |
| Benzene SCHEMBL26677210 | 0.67 | BCHE (0.48) | NPY5RKDM4ESMN1; SMN2NPSR1ALDH1A1 | |
| Pyrimidine SCHEMBL26677245 | 0.65 | BCHE (0.43) | NPY5RSMN1; SMN2NPSR1HPGDTSHR | |
| SCHEMBL25559304 | 0.63 | MEN1 (0.46) | NPY5RKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL27984526 | 0.63 | SMN1; SMN2 (0.41) | NPY5RSMN1; SMN2ALDH1A1 | |
| SCHEMBL9881482 | 0.61 | MAPT (0.44) | KDM4EHTTSMN1; SMN2MAPTNPSR1 | |
| SCHEMBL27984920 | 0.61 | SMN1; SMN2 (0.39) | LMNASMN1; SMN2MAPTALDH1A1HSD17B10 | |
| SCHEMBL10897306 | 0.61 | GABRA1 (0.51) | SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL5773947 | 0.60 | NPY5R (0.41) | NPY5RKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |