Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NT5E | P21589 | 3/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5771340 | 0.89 | MAPK14 (0.49) | MAPK14KDM4E | |
| SCHEMBL5774679 | 0.86 | MAPK14 (0.50) | MAPK14KDM4ESCN5A | |
| SCHEMBL5799661 | 0.83 | NT5E (0.45) | MAPK14KDM4ENT5ERETPIM1 | |
| SCHEMBL5773480 | 0.81 | MAPK14 (0.61) | MAPK14KDM4ENT5ESCN5ARET | |
| SCHEMBL5773959 | 0.80 | MAPK14 (0.60) | MAPK14 | |
| SCHEMBL5775474 | 0.79 | MAPK14 (0.58) | MAPK14KDM4ENT5ESCN5ARET | |
| SCHEMBL28329372 | 0.78 | ADORA1 (0.49) | MAPK14 | |
| SCHEMBL5775568 | 0.78 | MAPK14 (0.57) | MAPK14KDM4ENT5ESCN5ARET | |
| SCHEMBL15007181 | 0.77 | MAPK14 (0.60) | MAPK14KDM4ESCN5ARETPIM1 | |
| SCHEMBL19806385 | 0.76 | TGFBR1 (0.51) | MAPK14FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370559-B1 | TRIAZOLOPYRIDINES AS ANTI-INFLAMMATORY AGENTS | PFIZER PROD INC (US) | 2006-04-19 | — | — | EP | disclosed |
| EP-1370559-A1 | TRIAZOLOPYRIDINES AS ANTI-INFLAMMATORY AGENTS | Pfizer Products Inc. (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002072579-A1 | TRIAZOLOPYRIDINES AS ANTI-INFLAMMATORY AGENTS | PFIZER PRODUCTS INC. (US) | 2002-09-19 | — | — | WO | disclosed |