Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | TYK2 | P29597 | 4/20 | 0.53 |
| ▸ | JAK1 | P23458 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NGLY1 | Q96IV0 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10837028 | 0.79 | JAK2 (0.63) | JAK2TYK2JAK1JAK3MEN1 | |
| SCHEMBL29127218 | 0.77 | JAK2 (0.68) | JAK2TYK2JAK1JAK3MEN1 | |
| SCHEMBL5914015 | 0.75 | KMT2A (0.55) | NPC1RAB9AMEN1KMT2AMAPK10 | |
| SCHEMBL9409048 | 0.74 | MAPK10 (0.54) | JAK2TYK2JAK1JAK3NPC1 | |
| SCHEMBL11665185 | 0.74 | MEN1 (0.58) | JAK2TYK2JAK1JAK3NPC1 | |
| SCHEMBL18905565 | 0.72 | TYK2 (0.72) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL29421243 | 0.72 | MAPT (0.62) | JAK2TYK2JAK1JAK3NPC1 | |
| SCHEMBL11465530 | 0.71 | JAK2 (0.49) | JAK2TYK2JAK1JAK3NPC1 | |
| SCHEMBL5776205 | 0.70 | KMT2A (0.61) | NPC1RAB9AMEN1KMT2AMAPK10 | |
| SCHEMBL18894253 | 0.69 | TYK2 (1.00) | JAK2TYK2JAK1JAK3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060293503-A1 | Polyaminopyridines and method for producing same | SUMITOMO SEIKA CHEMICALS CO., LTD (JP) | 2006-12-28 | — | — | US | disclosed |
| EP-1669390-A1 | POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2006-06-14 | — | — | EP | disclosed |