Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775329 | 0.86 | KDM4E (0.45) | HSD17B10KDM4EALDH1A1HPGDNPY5R | |
| SCHEMBL5773349 | 0.86 | NPY5R (0.52) | HSD17B10KDM4ENPY5RKMT2AL3MBTL1 | |
| SCHEMBL5771896 | 0.86 | NPY5R (0.52) | HSD17B10KDM4ENPY5RKMT2AL3MBTL1 | |
| SCHEMBL5773681 | 0.85 | NPY5R (0.54) | HSD17B10KDM4EHPGDNPY5RKMT2A | |
| Hydrochloric Acid SCHEMBL5777287 | 0.84 | NPY5R (0.50) | HSD17B10KDM4ENPY5RKMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5776807 | 0.84 | NPY5R (0.50) | HSD17B10KDM4ENPY5RKMT2AL3MBTL1 | |
| SCHEMBL5772625 | 0.79 | MELK (0.45) | HSD17B10KDM4EALDH1A1HPGDNPY5R | |
| SCHEMBL5774815 | 0.79 | NPY5R (0.54) | HSD17B10KDM4EALDH1A1HPGDNPY5R | |
| SCHEMBL5772300 | 0.79 | HSD17B10 (0.42) | HSD17B10KDM4EALDH1A1HPGDNPY5R | |
| SCHEMBL5773980 | 0.78 | NPY5R (0.55) | HSD17B10KDM4EALDH1A1HPGDNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |