Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10515633 | 0.88 | MAPT (0.60) | MAPTMAPK1L3MBTL1HTTTSHR | |
| SCHEMBL26099558 | 0.83 | POLB (0.40) | MAPTMAPK1L3MBTL1TSHRALDH1A1 | |
| SCHEMBL5778792 | 0.83 | KDM4E (0.41) | MAPTMAPK1L3MBTL1HTTTSHR | |
| SCHEMBL12179887 | 0.83 | MAPT (0.56) | MAPTMAPK1L3MBTL1HTTTSHR | |
| SCHEMBL2589045 | 0.82 | MAPT (0.61) | MAPTMAPK1L3MBTL1HTTTSHR | |
| SCHEMBL30177224 | 0.82 | MAPT (0.61) | MAPTMAPK1L3MBTL1HTTTSHR | |
| SCHEMBL31539439 | 0.81 | MAPT (0.59) | MAPTMAPK1L3MBTL1HTTTSHR | |
| SCHEMBL10724543 | 0.81 | L3MBTL1 (0.53) | MAPTL3MBTL1TSHRALDH1A1HSD17B10 | |
| SCHEMBL7301123 | 0.79 | POLB (0.41) | MAPTL3MBTL1TSHRALDH1A1HSD17B10 | |
| SCHEMBL6988391 | 0.79 | HTT (0.49) | MAPTMAPK1L3MBTL1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652839-A2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1227084-B1 | DRUG DISCHARGE PUMP INHIBITORS | TRINE PHARMACEUTICALS INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | disclosed |