Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 19/20 | 0.66 |
| ▸ | GABRG2 | P18507 | 19/20 | 0.66 |
| ▸ | GABRB3 | P28472 | 19/20 | 0.66 |
| ▸ | GABRA3 | P34903 | 19/20 | 0.66 |
| ▸ | GABRA5 | P31644 | 16/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660285 | 0.96 | GABRA1 (0.71) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5774137 | 0.92 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5773973 | 0.89 | GABRA1 (0.65) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5774778 | 0.87 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2658863 | 0.86 | GABRA1 (0.69) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659070 | 0.86 | GABRA1 (0.63) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2660141 | 0.86 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5772495 | 0.85 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2658693 | 0.84 | GABRA1 (0.69) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659092 | 0.83 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511747-B1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-04-12 | — | — | EP | claimed |