Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 6/20 | 0.35 |
| ▸ | CX3CR1 | P49238 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774915 | 1.00 | CXCR2 (0.35) | CXCR2CX3CR1ADORA1ADORA2AADORA3 | |
| SCHEMBL5772029 | 0.79 | ADORA1 (0.52) | CXCR2CX3CR1ADORA1ADORA2AADORA3 | |
| SCHEMBL6216000 | 0.78 | MEN1 (0.46) | ADORA1ADORA2AADORA3ALDH1A1KDM4E | |
| SCHEMBL5774901 | 0.76 | NPY5R (0.57) | CXCR2 | |
| Hydrochloric Acid SCHEMBL5776353 | 0.69 | NPY5R (0.46) | ADORA1ADORA2AADORA3ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL5776728 | 0.68 | PDE5A (0.44) | ADORA1ADORA2AADORA3ALDH1A1KDM4E | |
| SCHEMBL5771208 | 0.68 | KDM4E (0.39) | ADORA1ADORA2AADORA3ALDH1A1KDM4E | |
| SCHEMBL5774513 | 0.67 | HIF1A (0.49) | ADORA1ADORA2AADORA3ALDH1A1KDM4E | |
| SCHEMBL5774357 | 0.67 | ADORA3 (0.48) | ADORA1ADORA2AADORA3ALDH1A1KDM4E | |
| SCHEMBL5776191 | 0.67 | KDM4E (0.40) | ADORA1ADORA2AADORA3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |