Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13606457 | 0.81 | PDE5A (0.45) | HTTPDE5AMEN1KMT2ANPC1 | |
| SCHEMBL4495080 | 0.81 | PDE5A (0.44) | HTTPDE5AMEN1KMT2ANPC1 | |
| SCHEMBL4498229 | 0.81 | PDE5A (0.44) | HTTPDE5AMEN1KMT2ANPC1 | |
| SCHEMBL4503766 | 0.79 | PDE5A (0.39) | HTTPDE5AMEN1KMT2ANPC1 | |
| SCHEMBL4503764 | 0.79 | NPC1 (0.40) | HTTPDE5AMEN1KMT2ANPC1 | |
| SCHEMBL4497191 | 0.79 | PDE5A (0.45) | HTTPDE5AMEN1KMT2ANPC1 | |
| SCHEMBL13606493 | 0.77 | CTSL (0.44) | HTTPDE5AMEN1KMT2ANPC1 | |
| SCHEMBL13606496 | 0.76 | CCNE2 (0.41) | HTTPDE5AMEN1KMT2ANPC1 | |
| SCHEMBL4509348 | 0.76 | PDE5A (0.45) | HTTPDE5AMEN1KMT2ANPC1 | |
| SCHEMBL11888473 | 0.71 | EGFR (0.47) | HTTPDE5AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556053-A4 | ANTIINFLAMMATION AGENTS | AMGEN INC (US) | 2006-04-19 | — | — | EP | disclosed |
| EP-1556053-A1 | ANTIINFLAMMATION AGENTS | Amgen Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041285-A1 | ANTIINFLAMMATION AGENTS | AMGEN INC. (US) | 2004-05-21 | — | — | WO | disclosed |