Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 17/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | PTGFR | P43088 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | GPR183 | P32249 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835901 | 0.78 | TBXA2R (0.69) | TBXA2RPTGER1PTGFRPTGER3PTGER2 | |
| SCHEMBL5798298 | 0.65 | TBXA2R (0.63) | TBXA2RPTGER1PTGFRPTGER3PTGER2 | |
| SCHEMBL14582545 | 0.61 | TBXA2R (0.65) | TBXA2RPTGER1PTGFRPTGER3PTGER2 | |
| SCHEMBL15281022 | 0.60 | SLC9A1 (0.49) | PTGDR2CNR2ALDH1A1 | |
| SCHEMBL8606110 | 0.59 | SMN1; SMN2 (0.51) | CNR2ALDH1A1 | |
| SCHEMBL5778175 | 0.59 | TBXA2R (0.49) | TBXA2RPTGDR2 | |
| SCHEMBL8490829 | 0.59 | AVPR2 (0.44) | CNR2ALDH1A1 | |
| SCHEMBL2126878 | 0.59 | SMN1; SMN2 (0.55) | ALDH1A1 | |
| SCHEMBL28647649 | 0.58 | HTT (0.42) | CNR2 | |
| SCHEMBL8491568 | 0.58 | CNR2 (0.39) | CNR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |