Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 6/20 | 0.42 |
| ▸ | GLA | P06280 | 4/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777019 | 0.89 | ALB (0.41) | KDM4EALDH1A1HSD17B10MAPTNPC1 | |
| SCHEMBL17802254 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10RECQL | |
| SCHEMBL9379333 | 0.74 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10RECQL | |
| SCHEMBL2220072 | 0.74 | KDM4E (0.58) | KDM4EALDH1A1HPGDHSD17B10RECQL | |
| SCHEMBL5779170 | 0.73 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10RECQL | |
| SCHEMBL5778337 | 0.69 | ALB (0.58) | KDM4EALDH1A1HPGDHSD17B10RECQL | |
| SCHEMBL10375651 | 0.68 | MAPT (0.60) | KDM4EALDH1A1HPGDHSD17B10RECQL | |
| SCHEMBL5777240 | 0.68 | MAPT (0.56) | ALDH1A1MAPTNPC1RAB9APOLB | |
| SCHEMBL10378127 | 0.67 | CYSLTR1 (0.42) | KDM4EALDH1A1HPGDHSD17B10RECQL | |
| SCHEMBL17808847 | 0.66 | KDM4E (0.60) | KDM4EALDH1A1HPGDHSD17B10RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652839-A2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1227084-B1 | DRUG DISCHARGE PUMP INHIBITORS | TRINE PHARMACEUTICALS INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | disclosed |