Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GUCY1B2 | O75343 | 5/20 | 0.35 |
| ▸ | GUCY1A2 | P33402 | 5/20 | 0.35 |
| ▸ | GUCY1A1 | Q02108 | 5/20 | 0.35 |
| ▸ | GUCY1B1 | Q02153 | 5/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776065 | 0.89 | KDM4E (0.46) | ALBMAPTPSEN1PSEN2APH1B | |
| SCHEMBL10379243 | 0.77 | PSEN1 (0.51) | TP53MAPTPSEN1PSEN2APH1B | |
| SCHEMBL14161885 | 0.77 | TP53 (0.46) | CHEK1LIMK1DYRK1ACLK4TP53 | |
| SCHEMBL11478098 | 0.68 | TP53 (0.48) | CHEK1LIMK1DYRK1ACLK4TP53 | |
| SCHEMBL1580228 | 0.68 | TP53 (0.62) | CHEK1LIMK1DYRK1ACLK4TP53 | |
| SCHEMBL17802254 | 0.68 | KDM4E (0.53) | TP53MAPTPSEN1PSEN2APH1B | |
| SCHEMBL17808842 | 0.67 | TP53 (0.53) | TP53MAPTPSEN1PSEN2APH1B | |
| SCHEMBL13313510 | 0.66 | CHEK1 (0.49) | CHEK1LIMK1DYRK1ACLK4TP53 | |
| SCHEMBL5779001 | 0.65 | MAPT (0.45) | ALBMAPTNPC1ALOX5APRAB9A | |
| SCHEMBL5908579 | 0.65 | ALB (0.43) | ALBTP53MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652839-A2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1227084-B1 | DRUG DISCHARGE PUMP INHIBITORS | TRINE PHARMACEUTICALS INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | disclosed |