Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3772534 | 0.81 | SMARCA2 (0.51) | HTR2CHTR2ASMARCA2SMARCA4MEN1 | |
| SCHEMBL6633482 | 0.79 | SMARCA2 (0.50) | HTR2CHTR2ASMARCA2SMARCA4MEN1 | |
| SCHEMBL8064953 | 0.79 | SMARCA2 (0.47) | HTR2CHTR2ASMARCA2SMARCA4MEN1 | |
| SCHEMBL11668320 | 0.79 | SMARCA2 (0.47) | HTR2CHTR2ASMARCA2SMARCA4MEN1 | |
| SCHEMBL14445424 | 0.78 | SMARCA2 (0.49) | HTR2CHTR2ASMARCA2SMARCA4MEN1 | |
| SCHEMBL11129213 | 0.78 | SMARCA2 (0.49) | HTR2CHTR2ASMARCA2SMARCA4MEN1 | |
| SCHEMBL11410175 | 0.76 | SMARCA2 (0.55) | HTR2CHTR2ASMARCA2SMARCA4MEN1 | |
| SCHEMBL11169351 | 0.76 | SMARCA2 (0.48) | HTR2CHTR2ASMARCA2SMARCA4MEN1 | |
| SCHEMBL11402099 | 0.75 | SMARCA2 (0.50) | HTR2CHTR2ASMARCA2SMARCA4MEN1 | |
| SCHEMBL12630113 | 0.75 | SMARCA2 (0.44) | HTR2CHTR2ASMARCA2SMARCA4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569644-A4 | INDOLIZINE COMPOUNDS | SYNTA PHARMACEUTICALS CORP (US) | 2006-08-30 | — | — | EP | disclosed |
| EP-1569644-A2 | INDOLIZINE COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004054507-A2 | INDOLIZINE COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2004-07-01 | — | — | WO | disclosed |