Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.61 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.61 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.61 |
| ▸ | KDM4A | O75164 | 1/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30362094 | 1.00 | KDM5A (0.61) | KDM5AKDM4CKDM5BKDM4ACCNB2 | |
| SCHEMBL3567059 | 0.77 | NPY5R (0.56) | KDM5AKDM4CKDM5BKDM4ACCNB2 | |
| SCHEMBL16149258 | 0.76 | KDM5A (1.00) | KDM5AKDM4CKDM5BKDM4A | |
| SCHEMBL5775164 | 0.74 | NPY5R (0.58) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| SCHEMBL31240593 | 0.73 | CDC7 (0.59) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| SCHEMBL16041244 | 0.73 | CDC7 (0.59) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| Hydrochloric Acid SCHEMBL5776488 | 0.72 | NPY5R (0.54) | KDM5AKDM4CKDM5BKDM4ACCNB2 | |
| SCHEMBL5771574 | 0.72 | NPY5R (0.65) | KDM5AKDM4CKDM5BKDM4ANPY5R | |
| SCHEMBL490933 | 0.72 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| SCHEMBL29912855 | 0.72 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076849-A1 | INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2023076849-A1 | INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |