Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.31 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724060 | 0.76 | IDH1 (0.31) | MAPTALDH1A1GLAHPGDACHE | |
| SCHEMBL577313 | 0.74 | CCR4 (0.39) | CCR4TYK2ALDH1A1HPGDCYP1A2 | |
| SCHEMBL577312 | 0.74 | CCR4 (0.39) | CCR4TYK2ALDH1A1HPGDCYP1A2 | |
| SCHEMBL576843 | 0.73 | CCR4 (0.38) | CCR4TYK2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL576844 | 0.73 | CCR4 (0.38) | CCR4TYK2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL3417300 | 0.72 | RAB9A (0.50) | MAPTALDH1A1GLAHPGDACHE | |
| SCHEMBL5279906 | 0.72 | MAPT (0.35) | MAPTALDH1A1GLAHPGDACHE | |
| SCHEMBL577568 | 0.71 | CCR4 (0.36) | CCR4TYK2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL577569 | 0.71 | POLB (0.41) | CCR4ALDH1A1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL2893870 | 0.70 | RAB9A (0.46) | MAPTALDH1A1GLAHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2461811-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS USEFUL AGAINST VIRAL INFECTIONS, PARTICULARLY HCV | IDENIX Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | disclosed |
| EP-2417134-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX Pharmaceuticals, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2011017389-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS USEFUL AGAINST VIRAL INFECTIONS, PARTICULARLY HCV | IDENIX PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2010118078-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |